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Exome sequence of probands in Barrett's oesophagus families

Dataset ID Technology Samples
EGAD00001002181 Illumina HiSeq 2000 6

Dataset Description

Barrett?s oesophagus is common in the UK affecting 2 % of the population. Family history has been recorded among the 4000 Barrett's cases collected so far and have 241 families. Among them we have assessed 6 multiplex families with proven Barrett?s and defined as having 1 pro band and at least 3 affected first degree members. We propose to exome sequence the probands of these six families to assess the presence of pathogenic rare coding variants.