Study
Integrative genomic analyses reveal androgen-driven somatic alteration landscape in early-onset prostate cancer
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00001000400 | Other |
Study Description
Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in eleven tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of >10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.
Study Datasets 6 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001000303 |
ICGC prostate cancer whole genome mate-pair sequencing
|
Illumina Genome Analyzer IIx | 22 |
EGAD00001000304 |
ICGC prostate cancer miRNA sequencing
|
Illumina HiSeq 2000 | 8 |
EGAD00001000305 |
ICGC prostate cancer RNA sequencing
|
Illumina HiSeq 2000 | 12 |
EGAD00001000306 |
ICGC prostate cancer whole genome sequencing
|
Illumina HiSeq 2000 | 22 |
EGAD00001000632 |
NA
|
AB SOLiD 4 System | 12 |
EGAD00001007861 |
This dataset contains 318 Tumor and Control WGS files submitted in another EGA box for samples for Gerhauser et al.,Cancer Cell, 2018, 34:996-1011. WGS and sequencing protocol was earlier described in Weischenfeldt et al, Cancer Cell, 2013.
|
Illumina HiSeq 2000 | 320 |
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