Study

Regions of common inter-individual DNA methylation differences in human monocytes.

Study ID Alternative Stable ID Type
EGAS00001002265 Other

Study Description

Based on whole genome bisulfite sequencing of five human monocytes from unrelated individuals, we have identified regions of common inter-individual DNA methylation differences, where methylation is inversely correlated with active histone marks, but not with the expression of the associated genes. Genome-wide association studies in 1128 individuals show that allelic DNA methylation is caused by genetic variation in cis. At some loci, DNA methylation appears to be affected also by genetic variation in trans.

Study Datasets 2 dataset.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003259 Regions of common inter-individual DNA methylation differences in human monocytes – potential function and genetic basis WGBS Data of Samples: 43_Hm03_BlMo_Ct, 43_Hm02_BlMo_Ct, 43_Hm05_BlMo_Ct, 43_Hm01_BlMo_Ct For details about sequencing or sample metadata check http://deep.dkfz.de/ Illumina HiSeq 2000 4
EGAD00010001294 Methylation data using 450K Illumina 450k 1128

Who archives the data?

Publications

Publications Citations
Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function.
Epigenetics Chromatin 10:2017 37
5