Most HCCs in Taiwan show the mutational signature of aristolochic acid

Study ID Alternative Stable ID Type
EGAS00001002301 Other

Study Description

Plants in the genus Aristolochia contain the mutagen aristolochic acid (AA) and have been widely used in traditional medicines and for weight loss. AA binds covalently to genomic DNA and induces a highly distinctive mutational signature. While AA involvement in urinary-tract cancers in Taiwan is known, the possible role of AA in hepatocellular carcinomas (HCCs) in Taiwan has not been examined. Here, we whole-exome sequenced 98 unselected HCCs from Taiwan and analyzed the mutational signatures for evidence of AA mutagenesis. Remarkably, more than 78% of HCCs showed strong evidence of AA mutagenesis, often associated with high mutation burdens. Non-synonymous mutations in genes known to be HCC driver genes were detected. Importantly, we elucidated the potential of immunotherapy in this cohort of liver cancer patients.

Study Datasets 2 dataset.

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Dataset ID Description Technology Samples
EGAD00001003466 This dataset contains 21 tumor-normal pairs of exome sequencing data of HCC patient from Chang Gung Memorial Hospital, Taiwan. Illumina HiSeq 2500 42
EGAD00001003467 This dataset contains 77 tumor-normal pairs of exome sequencing data of HCC patient from National Taiwan University, Taiwan. Illumina HiSeq 2500 154

Who archives the data?


Publications Citations
Advances in genomic hepatocellular carcinoma research.
Gigascience 7:2018 None