Study

Frequent mutation of the FOXA1 untranslated region in prostate cancer

Study ID Alternative Stable ID Type
EGAS00001003113 Other

Study Description

We sequenced the coding and untranslated regions of 72 prostate cancer driver genes in 712 plasma cell free DNA samples from 428 men with metastatic prostate cancer, in an effort to understand the role of untranslated region mutations in late stage prostate cancer.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001004208 Dataset contains targeted sequencing data of 712 plasma cell free DNA samples and 428 white blood cell samples collected from 428 men with metastatic prostate cancer. Target capture was performed using a hydridization-based custom Roche SeqCap EZ Choice kit, designed to capture all exons of 72 prostate cancer driver genes. Cell free DNA was extracted from 10 mL blood samples. Libraries were sequenced using Illumina HiSeq 2500 or Illumina MiSeq instruments to a median coverage of 750x. 62% of samples had ctDNA fraction above 2% of total cfDNA. Note that "Dataset type" is erroneously listed as "Amplicon sequencing", because "Captured-based targeted sequencing" or "Hybridization-based targeted sequencing" were not available options in EGA at the time of submission. Illumina HiSeq 2500 1140

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Publications

Publications Citations
Frequent mutation of the FOXA1 untranslated region in prostate cancer.
Commun Biol 1:2018 122
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