Study

International consensus definition of DNA methylation subgroups in juvenile myelomonocytic leukemia

Study ID Alternative Stable ID Type
EGAS00001004682 Other

Study Description

Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation (DNAme) patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. However, standardized approaches to classify JMML based on DNAme patterns are lacking. We therefore sought to define an international consensus for DNAme subgroups in JMML and develop classification methods for clinical implementation.

Study Datasets 3 dataset.

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Dataset ID Description Technology Samples
EGAD00010001998 DNA methylation analysis of JMML patients from Europe, Japan and USA using EPIC arrays Infinium HumanMethylation450K and EPIC BeadChip 32
EGAD00010001999 DNA methylation analysis of JMML patients from Europe, Japan and USA using 450k arrays Infinium HumanMethylation450K and EPIC BeadChip 292
EGAD00010002000 DNA methylation analysis of JMML patients from Europe, Japan and USA using EPIC arrays Infinium HumanMethylation450K and EPIC BeadChip 47

Who archives the data?

Publications

Publications Citations
International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia.
Clin Cancer Res 27:2021 158-168
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