Ultraviolet radiation drives mutations in a subset of mucosal melanomas
|Study ID||Alternative Stable ID||Type|
Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We present the largest cohort of mucosal melanomas of conjunctival origin to be analyzed by whole genome sequencing and show a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset could benefit from treatments currently used for common cutaneous melanoma.
Study Datasets 1 dataset.
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|EGAD00001006568||This dataset contains 20 whole genome sequences from 10 tumor-normal pairs from conjunctival melanomas.||20|
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Ultraviolet radiation drives mutations in a subset of mucosal melanomas.
Nat Commun 12:2021 259