Study

Characterization of T cell tumor infiltration in brain metastases through the analysis of the cerebrospinal fluid

Study ID Alternative Stable ID Type
EGAS00001004751 Cancer Genomics

Study Description

Study Datasets 3 dataset.

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Dataset ID Description Technology Samples
EGAD00001006451 A total of 9 brain metastasis were sequenced. For 6/9 a matched cerebrospinal fluid sample, prior to surgery and in two cases after surgery (+1 month from surgery) and after treatment (+3 month) were collected. Single-cell T cell receptor clonotypes were produced using the Chromium Single Cell 5’ Library and sequenced on an Illumina NovaSeq 6000. Illumina NovaSeq 6000 17
EGAD00001006452 A total of 9 brain metastasis were sequenced. For 6/9 a matched cerebrospinal fluid sample, prior to surgery and in two cases after surgery (+1 month from surgery) and after treatment (+3 month) were collected. Single-cell gene expression was produced using the Chromium Single Cell 5’ Library and sequenced on an Illumina NovaSeq 6000. Illumina NovaSeq 6000 19
EGAD00001006453 Whole exome sequencing of matched tumor (brain metastasis) -normal (blood) from 6 patients. Illumina HiSeq 2500 12

Who archives the data?

Publications

Publications Citations
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment.
Nat Commun 12:2021 1503
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