Boson HCV infected liver bulk RNASeq study

Study ID Alternative Stable ID Type
EGAS00001004996 Other

Study Description

ACE2 is a receptor for the SARS-CoV-2 and differences in its expression may affect susceptibility to infection. In a genome-wide eQTL analysis using hepatitis C virus-infected liver tissue, we discovered that polymorphism in a type III interferon gene (IFNL4), which eliminates IFN-lambda-4 production, is associated with a two-fold increase in ACE2 RNA expression. Conversely, among genes negatively correlated with ACE2 expression, IFN-signalling pathways were highly enriched and ACE2 was downregulated after IFN-alpha treatment.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001006911 Bulk RNAseq from HCV infected liver biopsies. Two fastq files per sample for Paired end sequecing. Some samples were sequenced on multiple plates. Illumina HiSeq 4000 225

Who archives the data?

There are no publications available