Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
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The international TEsticular CAncer Consortium (TECAC) combined information from five GWAS (3,558 TGCT cases and 13,970 controls) to identify novel susceptibility loci. Using observed and imputed data, we conducted a fixed effects meta-analysis, including the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P<5x10-8). Most loci harbor biologically plausible candidate genes. We also refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son risk, 8% of which can be attributed to the 12 new signals reported here. Our new findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues into the biological etiology of TGCT.
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