DAC for Familial Melanoma Sequencing study

Dac ID Contact Person Email Access Information
EGAC00001000005 David Adams da1 [at] sanger [dot] ac [dot] uk No additional information is available

This DAC controls 2 datasets:

Dataset ID Description Technology Samples
EGAD00001000016 Familial Melanoma Sequencing Illumina Genome Analyzer II,Illumina HiSeq 2000 89
EGAD00001001124 Our aim is to analyze the genome of human melanoma cell lines and short term culture from human melanoma samples in order to identify genes that confer drug resistance to clinically relevant targeted therapies. We will perform whole-exome sequencing, copy number variation analysis and methylome analysis in a collection of human melanoma cell lines and short term culture that will be then screened for drug sensitivity/resistance through a library of clinically relevant drugs and drug combinations. By the combined analysis of the genomic lesion and the drug sensitivity/resistance profile of different cell lines, we will look for genes whose mutation is associated to the sensitivity or resistance to a specific drug in different samples. Illumina HiSeq 2000 14