DAC

University of Heidelberg_MUO

Dac ID Contact Person Email Access Information
EGAC00001000470 Stefan Duensing stefan [dot] duensing [at] med [dot] uni-heidelberg [dot] de No additional information is available

This DAC controls 2 datasets:

Dataset ID Description Technology Samples
EGAD00001002067 Renal cell carcinoma (RCC) is a genomically heterogeneous tumor. In the present project, the question whether intratumoral heterogeneity follows a zonal pattern indicating spatial niches was addressed. Whole exome sequencing of 16 paired samples from tumor periphery and center revealed a number of region-specific functional SNVs and Indels. Therefore, RCCs are not composed of evenly admixed tumor cells but show topological differences in their clonal composition. Illumina HiSeq 2500 16
EGAD00001004887 We performed multiregion whole exome sequencing of a total of 37 samples from five consecutive patients (normal tissue, n=5; primary tumors, n=16; tumor thrombi, n=16) to >35-fold target coverage. Matching primary tumor and venous tumor thrombus samples were analyzed. Four patients had a clear cell RCC, one patient had a poorly differentiated type II papillary RCC (RCC-VTT-04). The latter patient had a friable thrombus, the others were of solid consistency. Illumina HiSeq 2500 37