Using iPSC-derived neurons to explore cellular phenotypes associated with schizophrenia Data Access Committee.

Dac ID Contact Person Email Access Information
EGAC00001000870 Dr. Owen Dando owen [dot] dando [at] ed [dot] ac [dot] uk No additional information is available

This DAC controls 1 dataset:

Dataset ID Description Technology Samples
EGAD00001004064 This dataset contains high-throughput RNA-sequencing of 12 samples, each sample comprising neural precursor cells derived from human induced pluripotent stem cells from individuals with and without the 16p13.11 microduplication (a copy number variant associated with a range of neurodevelopmental disorders). 4 samples derive from patients carrying the 16p13.11 microduplication, and 8 derive from unaffected family controls. RNA samples were processed to deplete rRNA using the TruSeq Stranded Total RNA with Ribo-Gold kit. Libraries were then sequenced using the NextSeq 500/550 High-Output v2 Kit on the Illumina NextSeq 550 platform, to produce 75 base pair paired-end sequencing reads at an average depth of around 100 million reads per sample. Raw sequencing reads data are stored in two FASTQ files per sample for these paired-end reads. NextSeq 550 12