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UCL Centre for Longitudinal Studies

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UCL Centre for Longitudinal Studies
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This DAC controls 2 datasets

Dataset ID	Description	Technology	Samples
EGAD00001001021	Birth cohort studies involve repeated surveys of large numbers of individuals from birth and throughout their lives. They collect information useful for a wide range of life course research domains, alongside biological samples that can be used to generate genomic and other omic data. This rich source of longitudinal data, when combined with genomic data, offers the scientific community valuable insights from population genetics to rare disease associations. The 1958 National Child Development Study (NCDS) is following the lives of an initial 17,415 people born in England, Scotland, and Wales in a single week of 1958. The study started in 1958 at birth as the Perinatal Mortality Survey. It has tracked topics such as physical and mental health, cognitive ability, and social and economic status across the life course. Available here are whole-exome sequencing data from 1,000 NCDS cohort members generated as part of the ICR1000 UK Exome Series. The dataset comprises 2,000 FASTQ files containing paired-end sequence reads (forward and reverse reads) from 1,000 individuals. Further details of the study and sequencing resource are available in the associated publication: https://doi.org/10.12688/f1000research.7049.1. Accompanying phenotypic data are available through application to CLS. 1,000 samples – Illumina TruSeq library prep HiSeq2500; 2×101 bp reads). – 7.7 TB.	Illumina HiSeq 2500	1000
EGAD00001004396	Birth cohort studies involve repeated surveys of large numbers of individuals from birth and throughout their lives. They collect information useful for a wide range of life course research domains, alongside biological samples that can be used to generate genomic and other omic data. This rich source of longitudinal data, when combined with genomic data, offers the scientific community valuable insights from population genetics to rare disease associations. The 1958 National Child Development Study (NCDS) is following the lives of an initial 17,415 people born in England, Scotland, and Wales in a single week of 1958. The study started in 1958 at birth as the Perinatal Mortality Survey. It has tracked topics such as physical and mental health, cognitive ability, and social and economic status across the life course. Available here are exome sequence alignment files from 648 participants in the 1958 National Child Development Study (NCDS), generated as part of the ICR MOPOPGEN UK Exome Control Series. The dataset comprises 648 BAM files aligned to the hg17 reference genome. Further details of the sequencing resource are available in the associated publications: https://doi.org/10.1038/ncomms11883 and https://doi.org/10.1038/ncomms13840. Accompanying phenotypic data are available through application to CLS. 648 samples – Illumina HiSeq 2500 – 3.5 TB.	Illumina HiSeq 2500	648