ICR Evolutionary Genomics and Modelling

Dac ID Contact Person Email Access Information
EGAC00001001050 Andrea Sottoriva andrea [dot] sottoriva [at] icr [dot] ac [dot] uk No additional information is available

This DAC controls 3 datasets:

Dataset ID Description Technology Samples
EGAD00001004420 Whole exome and targeted sequencing data from 11 glioblastoma multiforme patients. A total of 70 tumour specimens and 11 blood samples were used for whole exome sequencing (WES) using the Agilent SureSelectXT Human All Exon V5 Kit. Two custom targeted sequencing panels were designed using the using Agilent’s Haloplex (TES1) or Agilent SureSelect XT2 technology (TES2). Libraries were sequenced on an Illumina HiSeq2500 Illumina HiSeq 2500 194
EGAD00001005507 NA Illumina HiSeq 4000,Illumina NovaSeq 6000 25
EGAD00001005782 This dataset contains 9 bam files of exome sequencing for an experiment of evolved resistance. Here a barcoded cell line (HCC827 - POT) has been treated under high concentrations of gefitinib (GEF) and trametinib (TRM) until resistance has evolved, as well as under control conditions (DMSO). The dataset contains exome sequencing of confluent cells for three replicates for each anti-cancer drug as well as two replicates of growth under DMSO conditions. The original barcoded cell line (POT) was also exome sequenced and is included in the cohort. Sequencing was performed on the Illumina NovaSeq platform. Illumina NovaSeq 6000 9