Mutated H3 Histones Drive Human Pre-Leukemic Hematopoietic Stem Cell Expansion And Promote Leukemic Aggressiveness.

Dac ID Contact Person Email Access Information
EGAC00001001054 Nikoleta Juretic nikoleta [dot] juretic [at] mail [dot] mcgill [dot] ca No additional information is available

This DAC controls 2 datasets:

Dataset ID Description Technology Samples
EGAD00001004436 Exome sequencing was performed on samples from patients 064, 105, and 8760, including the remission sample for 105. Exomes were captured using the Agilent SureSelect All Exon kit v5 kit and libraries sequenced on HiSeq 2000 or 2500 or 4000. Illumina HiSeq 2000,Illumina HiSeq 2500,Illumina HiSeq 4000 6
EGAD00001004437 RNA-seq data from TEX cells transduced with HIST1H3H WT, HIST1H3H K27M, HIST1H3F WT, HIST1H3F K27I and Luc2 control in triplicate. In addition, RNA-Seq was performed on untransduced TEX cells. Libraries [rRNA-depleted stranded (HMR)] were sequenced on an Illumina Hiseq 4000 platform to generate 100 bp paired-end reads. Illumina HiSeq 4000 18