DAC for Enhancer-gene rewiring in the pathogenesis of Quebec Platelet Disorder

Dac ID Contact Person Email Access Information
EGAC00001001529 Catherine P.M. Hayward haywrdc [at] mcmaster [dot] ca No additional information is available

This DAC controls 2 datasets:

Dataset ID Description Technology Samples
EGAD00001006048 ChIP-seq was performed for the following histone modifications in both megakaryocytes and granulocytes: H3K27ac, H3K4me2, and H3K36me3. ChIP-seq was performed for H3K27me3 and CTCF in megakaryocytes only. All ChIP experiments consist of n=3 replicates for each of QPD and Control, with the exception of control granulocyte H3K4me2 for which only n=2 replicates were performed. 4C-seq datasets consist of 2 viewpoints (PLAU promoter and an intergenic enhancer), profiled in megakaryocytes from n=2 controls and n=4 QPD. Illumina HiSeq 2500 77
EGAD00001006053 RNA-seq was performed on cultured megakaryocytes and peripheral-blood derived granulocytes from individuals with QPD and a unaffected controls. Each group consisted of n=3 biological replicates. Illumina HiSeq 2500 12