The EMC-NICHE DAC considers appeals for hematopoietic/niche-related data sets.

Marc H.G.P. Raaijmakers
m.h.g.raaijmakers@erasmusmc.nl

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Dataset ID	Description	Technology	Samples
EGAD00001006914	None	Illumina HiSeq 2500	9
EGAD00001011056	bulk RNAseq was conducted on highly purified CD45 - CD71 - CD235a - CD31 - CD271 + BMSCs isolated from a cohort of newly diagnosed 62 AML patients, uniformly treated within an intensive chemotherapy clinical trial and selected to represent the mutational landscape of AML	Illumina NovaSeq 6000	70
EGAD00001011057	To generate a cellular taxonomy of the human NBM and AML, representing both rare hematopoietic stem/progenitor cells (HSPCs) and stromal niche populations, allowing assessment of their cellular diversity and predicted intercellular signaling, we performed single cell RNA sequencing (scRNAseq) on viably frozen bone marrow (BM) aspirates from four healthy donors and 6 NPM1+ AML patients at diagnosis	Illumina NovaSeq 6000	20
EGAD00001015770	Mechanisms of clonal evolution in myeloid neoplasms remain incompletely understood. Darwinian theory predicts that the (micro)environment of clone-propagating stem cells may contribute to clonal selection. Here, we provide data fitting this model, establishing a relationship between stromal niche inflammation, inflammatory stress in HSPCs, clonal resistance and leukemic evolution in human MDS.	Illumina NovaSeq 6000	1
EGAD00001015771	To profile transcriptional alterations of HSPCs in LR-MDS patients, 7AAD−CD45+Lin-CD235a−CD34+ cells were isolated from healthy donors and LR-MDS patients for RNA sequencing.	Illumina NovaSeq 6000	1