DAC

VIB-KULeuven-CCB

Dac ID Contact Person Email Access Information
EGAC00001002005 Sofie Demeyer sofie [dot] demeyer [at] kuleuven [dot] be No additional information is available

This DAC controls 1 dataset:

Dataset ID Description Technology Samples
EGAD00001007010 This dataset contains all sequencing data of the publication "Oncogenic cooperation between the TCF7-SPI1 fusion and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia." This is bulk RNA sequencing of 4 T-ALL patients (X09, XB37, XB41 and XB47) of which X09 has a TCF7-SPI1 fusion, single cell RNA sequencing of these 4 patients toghether with a PDX model of the X09 patient and two patients from another cohort (SJTALL030263 and SJTALL031201) which also have a TCF7-SPI1 fusion, and nanopore sequencing of all patients with the TCF7-SPI1 fusion. Moreover these patient samples with the fusion where treated with PKF 118-310, and bulk RNA sequencing was performed in triplicate to determine the differentially expressed genes. GridION,Illumina HiSeq 4000,unspecified 38