Asan Medical Center Data Access Committee

Dac ID Contact Person Email Access Information
EGAC00001002143 Hee Jin Lee backlila [at] gamil [dot] com No additional information is available

This DAC controls 1 dataset:

Dataset ID Description Technology Samples
EGAD00001007733 High-precision human leukocyte antigen (HLA) genotyping is crucial for anti-cancer immunotherapy, but existing tools predicting HLA genotypes using next-generation sequencing (NGS) data are insufficiently accurate. We compared the availability and accuracy of eight HLA genotyping tools (OptiType, HLA-HD, PHLAT, seq2HLA, arcasHLA, HLAscan, HLA*LA, and Kourami) using 1,275 cases from the 1000 Genomes Project data and created a new HLA-genotyping algorithm combining tools. Then, we assessed the new algorithm’s performance in 39 in-house samples with normal whole-exome sequencing (WES) data and polymerase chain reaction–sequencing-based typing (PCR-SBT) results. Illumina HiSeq 2500 39