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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes (T2D) risk and related glycemic traits. However, little is known about the function of the zinc finger transcription factor RREB1 in glucose homeostasis or how changes in its expression and/or function influence diabetes risk. We studied its function using three transcriptomic strategies, profiling gene expression when RREB1 is knocked out or knocked down in the Endo-betaH1 cell line, in addition to the in vitro differentiation in hiPSCs.

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Data Access Policy of the Datasets from the Translational Genomics of Diabetes Lab at Stanford University

RNA-seq profiling of RREB1 knock out, knock down, and stem cell differentiation DATA ACCESS AGREEMENT This agreement governs the terms on which access will be granted to the RNA sequencing data generated as part of the RREB1 study. In signing this agreement, You are agreeing to be bound by the terms and conditions of access set out in this agreement. For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User’s Institution (as defined below). User Institution and User are referred to within the agreement as “You” and “Your” shall be construed accordingly. Definitions: Investigators means the group of investigators based in Stanford, US and Oxford, UK which have generated the Data. Data means all and any human genetic data obtained from the Investigators. Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto. User means a researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. User Institution means the organization at which the User is employed, affiliated or enrolled. Terms and Conditions: In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the Data or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevant access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outside the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives. 8. You accept that the Investigators, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a. bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b. accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 9. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 10. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 11. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 12. You accept that it may be necessary for the Investigators or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Investigators or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 13. You accept that the Data is protected by and subject to international laws and that You are responsible for ensuring compliance with any such applicable law. The Translational Genomics of Diabetes Lab Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA. 14. This agreement shall be construed, interpreted and governed by the laws of US and UK and shall be subject to the non-exclusive jurisdiction of the US and UK courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006314 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006204958 fastq.gz 1.2 GB
EGAF00006204959 fastq.gz 1.3 GB
EGAF00006204960 fastq.gz 1.1 GB
EGAF00006204961 fastq.gz 1.2 GB
EGAF00006204962 fastq.gz 1.2 GB
EGAF00006204963 fastq.gz 1.3 GB
EGAF00006204964 fastq.gz 1.3 GB
EGAF00006204965 fastq.gz 1.4 GB
EGAF00006204966 fastq.gz 1.2 GB
EGAF00006204967 fastq.gz 1.3 GB
EGAF00006204968 fastq.gz 1.2 GB
EGAF00006204969 fastq.gz 1.3 GB
EGAF00006204970 fastq.gz 1.2 GB
EGAF00006204971 fastq.gz 1.3 GB
EGAF00006204972 fastq.gz 1.2 GB
EGAF00006204973 fastq.gz 1.3 GB
EGAF00006204974 fastq.gz 1.3 GB
EGAF00006204975 fastq.gz 1.4 GB
EGAF00006204976 fastq.gz 1.2 GB
EGAF00006204977 fastq.gz 1.3 GB
EGAF00006204978 fastq.gz 1.2 GB
EGAF00006204979 fastq.gz 1.3 GB
EGAF00006204980 fastq.gz 297.3 MB
EGAF00006204981 fastq.gz 331.0 MB
EGAF00006204982 fastq.gz 340.9 MB
EGAF00006204983 fastq.gz 381.1 MB
EGAF00006204984 fastq.gz 370.1 MB
EGAF00006204985 fastq.gz 410.3 MB
EGAF00006204986 fastq.gz 298.9 MB
EGAF00006204987 fastq.gz 336.0 MB
EGAF00006204988 fastq.gz 346.8 MB
EGAF00006204989 fastq.gz 384.8 MB
EGAF00006204990 fastq.gz 300.8 MB
EGAF00006204991 fastq.gz 340.9 MB
EGAF00006204992 fastq.gz 360.7 MB
EGAF00006204993 fastq.gz 403.8 MB
EGAF00006204994 fastq.gz 317.0 MB
EGAF00006204995 fastq.gz 358.6 MB
EGAF00006204996 fastq.gz 305.0 MB
EGAF00006204997 fastq.gz 344.7 MB
EGAF00006204998 fastq.gz 301.2 MB
EGAF00006204999 fastq.gz 337.0 MB
EGAF00006205000 fastq.gz 324.4 MB
EGAF00006205001 fastq.gz 359.8 MB
EGAF00006205002 fastq.gz 276.7 MB
EGAF00006205003 fastq.gz 307.9 MB
EGAF00006205004 fastq.gz 321.9 MB
EGAF00006205005 fastq.gz 364.9 MB
EGAF00006205006 fastq.gz 311.5 MB
EGAF00006205007 fastq.gz 348.0 MB
EGAF00006205008 fastq.gz 297.6 MB
EGAF00006205009 fastq.gz 334.7 MB
EGAF00006205010 fastq.gz 421.0 MB
EGAF00006205011 fastq.gz 472.5 MB
EGAF00006205012 fastq.gz 313.5 MB
EGAF00006205013 fastq.gz 351.9 MB
EGAF00006205014 fastq.gz 348.1 MB
EGAF00006205015 fastq.gz 390.4 MB
EGAF00006205016 fastq.gz 349.8 MB
EGAF00006205017 fastq.gz 394.3 MB
EGAF00006205018 fastq.gz 306.6 MB
EGAF00006205019 fastq.gz 338.7 MB
EGAF00006205020 fastq.gz 351.8 MB
EGAF00006205021 fastq.gz 392.6 MB
EGAF00006205022 fastq.gz 326.1 MB
EGAF00006205023 fastq.gz 359.4 MB
EGAF00006205024 fastq.gz 320.1 MB
EGAF00006205025 fastq.gz 357.5 MB
EGAF00006205026 fastq.gz 277.9 MB
EGAF00006205027 fastq.gz 312.1 MB
EGAF00006205028 fastq.gz 391.1 MB
EGAF00006205029 fastq.gz 433.5 MB
EGAF00006205030 fastq.gz 326.9 MB
EGAF00006205031 fastq.gz 363.7 MB
EGAF00006205032 fastq.gz 306.0 MB
EGAF00006205033 fastq.gz 343.2 MB
EGAF00006205034 fastq.gz 318.9 MB
EGAF00006205035 fastq.gz 358.0 MB
EGAF00006205036 fastq.gz 282.2 MB
EGAF00006205037 fastq.gz 296.9 MB
EGAF00006205038 fastq.gz 315.8 MB
EGAF00006205039 fastq.gz 350.2 MB
EGAF00006205040 fastq.gz 347.5 MB
EGAF00006205041 fastq.gz 394.5 MB
EGAF00006205042 fastq.gz 276.4 MB
EGAF00006205043 fastq.gz 309.2 MB
EGAF00006205044 fastq.gz 354.4 MB
EGAF00006205045 fastq.gz 394.9 MB
EGAF00006205046 fastq.gz 340.3 MB
EGAF00006205047 fastq.gz 382.2 MB
EGAF00006205048 fastq.gz 302.0 MB
EGAF00006205049 fastq.gz 338.3 MB
EGAF00006205050 fastq.gz 274.5 MB
EGAF00006205051 fastq.gz 305.5 MB
EGAF00006205052 fastq.gz 347.0 MB
EGAF00006205053 fastq.gz 382.7 MB
EGAF00006205054 fastq.gz 310.2 MB
EGAF00006205055 fastq.gz 345.2 MB
EGAF00006205056 fastq.gz 320.9 MB
EGAF00006205057 fastq.gz 361.9 MB
EGAF00006205058 fastq.gz 314.9 MB
EGAF00006205059 fastq.gz 354.5 MB
EGAF00006205060 fastq.gz 315.9 MB
EGAF00006205061 fastq.gz 357.0 MB
EGAF00006205062 fastq.gz 316.5 MB
EGAF00006205063 fastq.gz 355.4 MB
EGAF00006205064 fastq.gz 285.2 MB
EGAF00006205065 fastq.gz 316.6 MB
EGAF00006205066 fastq.gz 309.5 MB
EGAF00006205067 fastq.gz 343.1 MB
EGAF00006205068 fastq.gz 339.7 MB
EGAF00006205069 fastq.gz 374.5 MB
EGAF00006205070 fastq.gz 344.8 MB
EGAF00006205071 fastq.gz 381.2 MB
EGAF00006205072 fastq.gz 336.9 MB
EGAF00006205073 fastq.gz 376.2 MB
EGAF00006205074 fastq.gz 363.8 MB
EGAF00006205075 fastq.gz 405.8 MB
EGAF00006205076 fastq.gz 326.7 MB
EGAF00006205077 fastq.gz 363.0 MB
EGAF00006205078 fastq.gz 290.8 MB
EGAF00006205079 fastq.gz 330.2 MB
EGAF00006205080 fastq.gz 334.8 MB
EGAF00006205081 fastq.gz 381.6 MB
EGAF00006205082 fastq.gz 364.5 MB
EGAF00006205083 fastq.gz 410.3 MB
EGAF00006205084 fastq.gz 291.5 MB
EGAF00006205085 fastq.gz 334.8 MB
EGAF00006205086 fastq.gz 341.2 MB
EGAF00006205087 fastq.gz 384.6 MB
EGAF00006205088 fastq.gz 295.8 MB
EGAF00006205089 fastq.gz 341.4 MB
EGAF00006205090 fastq.gz 355.5 MB
EGAF00006205091 fastq.gz 406.7 MB
EGAF00006205092 fastq.gz 311.1 MB
EGAF00006205093 fastq.gz 359.7 MB
EGAF00006205094 fastq.gz 301.2 MB
EGAF00006205095 fastq.gz 346.0 MB
EGAF00006205096 fastq.gz 298.1 MB
EGAF00006205097 fastq.gz 340.1 MB
EGAF00006205098 fastq.gz 319.9 MB
EGAF00006205099 fastq.gz 361.9 MB
EGAF00006205100 fastq.gz 271.4 MB
EGAF00006205101 fastq.gz 306.6 MB
EGAF00006205102 fastq.gz 317.9 MB
EGAF00006205103 fastq.gz 366.8 MB
EGAF00006205104 fastq.gz 307.8 MB
EGAF00006205105 fastq.gz 349.0 MB
EGAF00006205106 fastq.gz 292.5 MB
EGAF00006205107 fastq.gz 334.6 MB
EGAF00006205108 fastq.gz 413.8 MB
EGAF00006205109 fastq.gz 472.1 MB
EGAF00006205110 fastq.gz 304.8 MB
EGAF00006205111 fastq.gz 349.8 MB
EGAF00006205112 fastq.gz 342.1 MB
EGAF00006205113 fastq.gz 389.8 MB
EGAF00006205114 fastq.gz 345.0 MB
EGAF00006205115 fastq.gz 396.9 MB
EGAF00006205116 fastq.gz 302.1 MB
EGAF00006205117 fastq.gz 339.6 MB
EGAF00006205118 fastq.gz 347.4 MB
EGAF00006205119 fastq.gz 395.5 MB
EGAF00006205120 fastq.gz 320.9 MB
EGAF00006205121 fastq.gz 360.3 MB
EGAF00006205122 fastq.gz 314.5 MB
EGAF00006205123 fastq.gz 358.5 MB
EGAF00006205124 fastq.gz 272.1 MB
EGAF00006205125 fastq.gz 311.2 MB
EGAF00006205126 fastq.gz 384.1 MB
EGAF00006205127 fastq.gz 433.7 MB
EGAF00006205128 fastq.gz 321.5 MB
EGAF00006205129 fastq.gz 364.7 MB
EGAF00006205130 fastq.gz 302.4 MB
EGAF00006205131 fastq.gz 345.7 MB
EGAF00006205132 fastq.gz 315.5 MB
EGAF00006205133 fastq.gz 359.8 MB
EGAF00006205134 fastq.gz 276.2 MB
EGAF00006205135 fastq.gz 298.3 MB
EGAF00006205136 fastq.gz 312.1 MB
EGAF00006205137 fastq.gz 352.3 MB
EGAF00006205138 fastq.gz 341.4 MB
EGAF00006205139 fastq.gz 395.7 MB
EGAF00006205140 fastq.gz 270.1 MB
EGAF00006205141 fastq.gz 308.2 MB
EGAF00006205142 fastq.gz 348.9 MB
EGAF00006205143 fastq.gz 396.2 MB
EGAF00006205144 fastq.gz 332.9 MB
EGAF00006205145 fastq.gz 382.6 MB
EGAF00006205146 fastq.gz 297.1 MB
EGAF00006205147 fastq.gz 339.5 MB
EGAF00006205148 fastq.gz 271.7 MB
EGAF00006205149 fastq.gz 308.1 MB
EGAF00006205150 fastq.gz 342.7 MB
EGAF00006205151 fastq.gz 383.8 MB
EGAF00006205152 fastq.gz 305.7 MB
EGAF00006205153 fastq.gz 345.6 MB
EGAF00006205154 fastq.gz 315.7 MB
EGAF00006205155 fastq.gz 362.4 MB
EGAF00006205156 fastq.gz 309.7 MB
EGAF00006205157 fastq.gz 354.8 MB
EGAF00006205158 fastq.gz 307.7 MB
EGAF00006205159 fastq.gz 355.4 MB
EGAF00006205160 fastq.gz 311.8 MB
EGAF00006205161 fastq.gz 355.6 MB
EGAF00006205162 fastq.gz 281.0 MB
EGAF00006205163 fastq.gz 318.2 MB
EGAF00006205164 fastq.gz 305.3 MB
EGAF00006205165 fastq.gz 344.0 MB
EGAF00006205166 fastq.gz 334.6 MB
EGAF00006205167 fastq.gz 376.7 MB
EGAF00006205168 fastq.gz 339.2 MB
EGAF00006205169 fastq.gz 381.1 MB
EGAF00006205170 fastq.gz 330.3 MB
EGAF00006205171 fastq.gz 376.5 MB
EGAF00006205172 fastq.gz 360.1 MB
EGAF00006205173 fastq.gz 408.6 MB
EGAF00006205174 fastq.gz 318.2 MB
EGAF00006205175 fastq.gz 362.3 MB
EGAF00006205176 fastq.gz 291.6 MB
EGAF00006205177 fastq.gz 318.4 MB
EGAF00006205178 fastq.gz 338.4 MB
EGAF00006205179 fastq.gz 370.6 MB
EGAF00006205180 fastq.gz 366.0 MB
EGAF00006205181 fastq.gz 396.6 MB
EGAF00006205182 fastq.gz 293.9 MB
EGAF00006205183 fastq.gz 325.6 MB
EGAF00006205184 fastq.gz 341.6 MB
EGAF00006205185 fastq.gz 370.6 MB
EGAF00006205186 fastq.gz 357.0 MB
EGAF00006205187 fastq.gz 393.3 MB
EGAF00006205188 fastq.gz 312.9 MB
EGAF00006205189 fastq.gz 349.1 MB
EGAF00006205190 fastq.gz 301.3 MB
EGAF00006205191 fastq.gz 334.0 MB
EGAF00006205192 fastq.gz 298.5 MB
EGAF00006205193 fastq.gz 327.5 MB
EGAF00006205194 fastq.gz 321.8 MB
EGAF00006205195 fastq.gz 350.1 MB
EGAF00006205196 fastq.gz 272.3 MB
EGAF00006205197 fastq.gz 296.0 MB
EGAF00006205198 fastq.gz 321.0 MB
EGAF00006205199 fastq.gz 357.6 MB
EGAF00006205200 fastq.gz 309.4 MB
EGAF00006205201 fastq.gz 338.2 MB
EGAF00006205202 fastq.gz 293.6 MB
EGAF00006205203 fastq.gz 323.9 MB
EGAF00006205204 fastq.gz 416.6 MB
EGAF00006205205 fastq.gz 457.8 MB
EGAF00006205206 fastq.gz 305.7 MB
EGAF00006205207 fastq.gz 338.2 MB
EGAF00006205208 fastq.gz 342.2 MB
EGAF00006205209 fastq.gz 375.6 MB
EGAF00006205210 fastq.gz 347.2 MB
EGAF00006205211 fastq.gz 385.7 MB
EGAF00006205212 fastq.gz 303.7 MB
EGAF00006205213 fastq.gz 327.9 MB
EGAF00006205214 fastq.gz 348.9 MB
EGAF00006205215 fastq.gz 383.0 MB
EGAF00006205216 fastq.gz 321.5 MB
EGAF00006205217 fastq.gz 347.0 MB
EGAF00006205218 fastq.gz 314.4 MB
EGAF00006205219 fastq.gz 344.9 MB
EGAF00006205220 fastq.gz 272.4 MB
EGAF00006205221 fastq.gz 300.3 MB
EGAF00006205222 fastq.gz 383.5 MB
EGAF00006205223 fastq.gz 416.2 MB
EGAF00006205224 fastq.gz 322.8 MB
EGAF00006205225 fastq.gz 352.0 MB
EGAF00006205226 fastq.gz 304.0 MB
EGAF00006205227 fastq.gz 335.1 MB
EGAF00006205228 fastq.gz 318.5 MB
EGAF00006205229 fastq.gz 349.8 MB
EGAF00006205230 fastq.gz 280.0 MB
EGAF00006205231 fastq.gz 288.3 MB
EGAF00006205232 fastq.gz 312.0 MB
EGAF00006205233 fastq.gz 339.4 MB
EGAF00006205234 fastq.gz 342.6 MB
EGAF00006205235 fastq.gz 383.3 MB
EGAF00006205236 fastq.gz 270.4 MB
EGAF00006205237 fastq.gz 296.5 MB
EGAF00006205238 fastq.gz 350.7 MB
EGAF00006205239 fastq.gz 383.1 MB
EGAF00006205240 fastq.gz 335.0 MB
EGAF00006205241 fastq.gz 370.5 MB
EGAF00006205242 fastq.gz 298.3 MB
EGAF00006205243 fastq.gz 328.5 MB
EGAF00006205244 fastq.gz 273.6 MB
EGAF00006205245 fastq.gz 298.5 MB
EGAF00006205246 fastq.gz 343.9 MB
EGAF00006205247 fastq.gz 369.8 MB
EGAF00006205248 fastq.gz 306.7 MB
EGAF00006205249 fastq.gz 333.7 MB
EGAF00006205250 fastq.gz 316.9 MB
EGAF00006205251 fastq.gz 350.6 MB
EGAF00006205252 fastq.gz 311.3 MB
EGAF00006205253 fastq.gz 343.8 MB
EGAF00006205254 fastq.gz 309.1 MB
EGAF00006205255 fastq.gz 344.7 MB
EGAF00006205256 fastq.gz 312.8 MB
EGAF00006205257 fastq.gz 343.6 MB
EGAF00006205258 fastq.gz 282.1 MB
EGAF00006205259 fastq.gz 307.1 MB
EGAF00006205260 fastq.gz 307.0 MB
EGAF00006205261 fastq.gz 332.4 MB
EGAF00006205262 fastq.gz 335.9 MB
EGAF00006205263 fastq.gz 363.1 MB
EGAF00006205264 fastq.gz 340.1 MB
EGAF00006205265 fastq.gz 367.0 MB
EGAF00006205266 fastq.gz 329.7 MB
EGAF00006205267 fastq.gz 361.8 MB
EGAF00006205268 fastq.gz 361.6 MB
EGAF00006205269 fastq.gz 394.1 MB
EGAF00006205270 fastq.gz 319.0 MB
EGAF00006205271 fastq.gz 348.7 MB
EGAF00007335739 fastq.gz 1.3 GB
EGAF00007335740 fastq.gz 1.4 GB
EGAF00007335741 fastq.gz 296.6 MB
EGAF00007335742 fastq.gz 330.2 MB
EGAF00007335743 fastq.gz 1.6 GB
EGAF00007335744 fastq.gz 1.8 GB
EGAF00007335745 fastq.gz 1.3 GB
EGAF00007335746 fastq.gz 1.4 GB
EGAF00007335747 fastq.gz 1.2 GB
EGAF00007335748 fastq.gz 1.3 GB
EGAF00007335749 fastq.gz 1.3 GB
EGAF00007335750 fastq.gz 1.4 GB
EGAF00007335751 fastq.gz 1.4 GB
EGAF00007335752 fastq.gz 1.5 GB
EGAF00007335753 fastq.gz 1.4 GB
EGAF00007335754 fastq.gz 1.5 GB
EGAF00007335755 fastq.gz 1.3 GB
EGAF00007335756 fastq.gz 1.5 GB
EGAF00007335757 fastq.gz 1.3 GB
EGAF00007335758 fastq.gz 1.4 GB
EGAF00007335759 fastq.gz 1.0 GB
EGAF00007335760 fastq.gz 1.1 GB
EGAF00007335761 fastq.gz 1.1 GB
EGAF00007335762 fastq.gz 1.2 GB
EGAF00007335763 fastq.gz 1.2 GB
EGAF00007335764 fastq.gz 1.3 GB
EGAF00007338996 fastq.gz 1.3 GB
EGAF00007338997 fastq.gz 1.4 GB
342 Files (162.3 GB)