14371 results for ""Pennsylvania+German"+ACS+study+'Socius'+open+access"

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• Data Access Committee

  Dac EGAC00001002967

• Data Access Commitee

  Dac EGAC00001002970

• BilMBG Data Access Committee

  Dac EGAC01000000008

• MolPAGE Data Access Committee

  Dac EGAC01000000017

• NalaGenetics Data Access Committee

  Dac EGAC00001003475

• Wits Data Access Committee

  Dac EGAC00001003520

• UKHD Data Access Committee

  Dac EGAC00001003607

• PGP Data Access Committee

  Dac EGAC00001003587

• Maternal Plasma Folate and DNA Methylation in Epigenome-Wide Meta-Analysis of Newborns

  Folic acid is routinely recommended for women trying to conceive to ensure proper fetal development. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. This data represents meta-analysis results from a large epigenomics study to examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina's HumanMethyl450 (450K) Beadchip in 1,996 newborns from two European cohorts. Results for all CpGs analyzed (419,905) are provided. These data may be downloaded through the dbGaP Authorized Access portal under phg000701.v1.

  Study phs001059

• NOTCH-mutations drive immune-escape mechanisms in B cell malignancies

  Here we provide access to MCL expression data that were used for interrogating the molecular functions of NOTCH1 and NOTCH2, which are two of the most commonly mutated genes in CLL and MCL and associated with a poor clinical outcome. The mechanisms underlying how NOTCH1 contributes to disease progression, resistance to treatment and Richter’s transformation remain largely unknown. The main goal of this study is to compare the gene expression profile of primary MCL cells transduced with the intracellular part of NOTCH1 or NOTCH2 lacking of the PEST domain vs cells transduced with an empty vector.

  Study EGAS00001005793