Study

Massive Genomic Rearrangment Acquired in a Single Catastrophic Event During Cancer Development

Study ID Alternative Stable ID Type
EGAS00000000029 Whole Genome Sequencing

Study Description

Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatically acquired point mutations, insertions and deletions in these samples. This project will give unprecedented insights into mutational processes, cellular repair pathways and gene networks associated with renal cancer development.Agilent whole exome hybridisation capture will be performed on genomic DNA derived from 25 renal cancers and matched normal DNA from the same patients. Three lanes of Illumina GA sequencing will be performed on the resulting 50 exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001000002
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
Illumina Genome Analyzer,Illumina Genome Analyzer II 11

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