Study
Genome wide association study of Coeliac Disease
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00000000057 | Genotype |
Study Description
We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P(combined) < 5 x 10(-8)); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P < 0.0028, FDR 5%) with cis gene expression
Study Datasets 8 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00010000284 |
NBS control samples only (Hap300)
|
Illumina (Various) | 2500 |
EGAD00010000286 |
All cases and controls (Hap550)
|
11950 | |
EGAD00010000288 |
All cases and Finnish, Dutch, Italian control samples (Hap550)
|
6313 | |
EGAD00010000290 |
NBS control samples only (Hap550)
|
2276 | |
EGAD00010000292 |
All cases and Finnish, Dutch, Italian control samples (Hap300)
|
10339 | |
EGAD00010000294 |
1958BC control samples only (Hap300)
|
2436 | |
EGAD00010000296 |
1958BC control samples only (Hap550)
|
2224 | |
EGAD00010000298 |
All cases and controls (Hap300)
|
13761 |
Who archives the data?

Publications
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