ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

Study ID Alternative Stable ID Type
EGAS00000000075 Full Transcriptome Sequencing

Study Description

We have sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clear-cell carcinoma cell line and found somatic mutations in ARID1A (the AT-rich interactive domain 1A [SWI-like] gene) in 6 of the samples. ARID1A encodes BAF250a, a key component of the SWI–SNF chromatin remodeling complex. We sequenced ARID1A in an additional 210 ovarian carcinomas and a second ovarian clear-cell carcinoma cell line and measured BAF250a expression by means of immunohistochemical analysis in an additional 455 ovarian carcinomas

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Whole transcriptome sequence data from 18 ovarian clear-cell carcinoma samples and one TOV21G ovarian clear-cell carcinoma cell line
Illumina Genome Analyzer II 1

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