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A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected persons, all of whom were matched for ancestry. We used random-effects pooled analysis to test for association in the overall study population and in subgroups of subjects with childhood-onset asthma (defined as asthma developing before 16 years of age), later-onset asthma, severe asthma, and occupational asthma.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00000000073 1
EGAD00000000074 1
EGAD00000000075 1
EGAD00000000076 1
EGAD00000000077 1
EGAD00000000082 1
EGAD00000000083 1
EGAD00000000084 1
EGAD00000000085 1
EGAD00000000086 1
EGAD00000000087 1
EGAD00000000088 1
EGAD00000000089 1
EGAD00000000090 1
EGAD00000000091 1
EGAD00000000092 1
EGAD00000000093 1
EGAD00000000094 1
EGAD00000000101 1
EGAD00000000102 1
EGAD00000000103 1
EGAD00000000104 1
EGAD00000000105 1
EGAD00000000106 1
EGAD00000000107 1
EGAD00000000108 1
EGAD00000000109 1
Publications Citations
A large-scale, consortium-based genomewide association study of asthma.
N Engl J Med 363: 2010 1211-1221
1172
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
J Allergy Clin Immunol 130: 2012 861-8.e7
88
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
J Allergy Clin Immunol 132: 2013 313-20.e15
69
Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort.
J Asthma 53: 2016 775-782
16
Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma.
BMC Genet 17: 2016 102
1
Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.
PLoS Med 14: 2017 e1002294
42