WTCCC2 case-control study for Ulcerative Colitis - EGA European Genome-phenome Archive

Dataset ID	Description	Technology	Samples
EGAD00000000021	WTCCC2 project samples from 1958 British Birth Cohort		3000
EGAD00000000023	WTCCC2 project samples from National Blood Donors (NBS) Cohort		1
EGAD00000000025	WTCCC2 project Ulcerative Colitis (UC) samples	Affymetrix 6.0	2869

Publications	Citations
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. UK IBD Genetics Consortium, Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Wellcome Trust Case Control Consortium 2, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Deloukas P, Peltonen L, Mathew CG, Blackwell JM, Brown MA, Corvin A, McCarthy MI, Spencer CC, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP. Nat Genet 41: 2009 1330-1334	427
Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease. Sasaki MM, Skol AD, Hungate EA, Bao R, Huang L, Kahn SA, Allan JM, Brant SR, McGovern DP, Peter I, Silverberg MS, Cho JH, Kirschner BS, Onel K. Inflamm Bowel Dis 22: 2016 20-27	15
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network. Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG. Genome Med 8: 2016 76	15
SumHer better estimates the SNP heritability of complex traits from summary statistics. Speed D, Balding DJ. Nat Genet 51: 2019 277-284	234
shaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores. Kelemen M, Vigorito E, Fachal L, Anderson CA, Wallace C. Am J Hum Genet 111: 2024 1006-1017	16
A Polygenic Risk Analysis for Identifying Ulcerative Colitis Patients with European Ancestry. Liu L, Wu Y, Li Y, Li M. Genes (Basel) 15: 2024 684	1
Network medicine-based epistasis detection in complex diseases: ready for quantum computing. Hoffmann M, Poschenrieder JM, Incudini M, Baier S, Fritz A, Maier A, Hartung M, Hoffmann C, Trummer N, Adamowicz K, Picciani M, Scheibling E, Harl MV, Lesch I, Frey H, Kayser S, Wissenberg P, Schwartz L, Hafner L, Acharya A, Hackl L, Grabert G, Lee SG, Cho G, Cloward ME, Jankowski J, Lee HK, Tsoy O, Wenke N, Pedersen AG, Bønnelykke K, Mandarino A, Melograna F, Schulz L, Climente-González H, Wilhelm M, Iapichino L, Wienbrandt L, Ellinghaus D, Van Steen K, Grossi M, Furth PA, Hennighausen L, Di Pierro A, Baumbach J, Kacprowski T, List M, Blumenthal DB. Nucleic Acids Res 52: 2024 10144-10160	16