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The Genetic Analysis of multiple sclerosis

We created these data in order to identify genetic variants associated with increased susceptibility to multiple sclerosis. Cases from many parts of the world were genotyped with the Illumina 660 chip along with Swedish controls. In our analysis we also used control data from the WTCCC2 common UK controls and from other published studies.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00000000021 3000
EGAD00000000022 3000
EGAD00000000023 1
EGAD00000000024 1
EGAD00000000120 Human670-QuadCustom v1 11375
Publications Citations
Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.
Eur J Hum Genet 23: 2015 688-692
GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis.
Genes Immun 17: 2016 305-312
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.
Genome Med 8: 2016 76
Insular Celtic population structure and genomic footprints of migration.
PLoS Genet 14: 2018 e1007152
Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis.
Nat Genet 50: 2018 1081-1085
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
Science 365: 2019 eaav7188
Dutch population structure across space, time and GWAS design.
Nat Commun 11: 2020 4556
Distinguishing pedigree relationships via multi-way identity by descent sharing and sex-specific genetic maps.
Am J Hum Genet 108: 2021 68-83
The genetic history of Greenlandic-European contact.
Curr Biol 31: 2021 2214-2219.e4
An efficient method to identify, date, and describe admixture events using haplotype information.
Genome Res None: 2022 None
The Anglo-Saxon migration and the formation of the early English gene pool.
Nature 610: 2022 112-119
Imputed genomes and haplotype-based analyses of the Picts of early medieval Scotland reveal fine-scale relatedness between Iron Age, early medieval and the modern people of the UK.
PLoS Genet 19: 2023 e1010360