Study
METABRIC miRNA landscape
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00000000122 | Genotype/Expression |
Study Description
MicroRNAs (miRNAs) are key players in cancer pathogenesis1. They display differential expression across breast cancer subtypes, and play oncogenic and tumor-suppressive roles2-6. A systematic study of the global miRNA landscape in breast cancer and the factors shaping it has not been undertaken. Here we report the results of profiling miRNA expression in 1,302 breast tumors with detailed clinical annotation and long-term follow-up, and for which matching genomic and mRNA expression data were available7. This provides a comprehensive view of the quantity, distribution and variation of the miRNA population and dissects how much genomic, transcriptional and post-transcriptional events contribute to miRNA expression architecture. The key clinical parameters and cellular pathways related to the miRNA landscape are identified, exemplified by context-dependent interaction with cell adhesion and Wnt signaling. Strikingly, in breast cancer miRNAs appear to act as modulators of mRNA-mRNA interactions rather than molecular switches. We demonstrate an important modulatory role for miRNAs in the ... (Show More)
Study Datasets 6 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00010000434 |
Normalised mRNA expression
|
Illumina HT 12 | 1302 |
EGAD00010000436 |
Illumina HT 12 IDAT files
|
Illumina HT 12 | 1302 |
EGAD00010000438 |
Normalized miRNA expression data
|
Agilent ncRNA 60k | 1480 |
EGAD00010000440 |
Segmented copy number data
|
Affymetrix_SNP6_raw | 1302 |
EGAD00010000442 |
Affymetrix SNP 6.0 CEL files
|
Affymetrix_SNP6_raw | 1302 |
EGAD00010000444 |
Agilent ncRNA 60k txt files
|
Agilent ncRNA 60k | 1480 |
Who archives the data?

Publications
Citations
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