METABRIC miRNA landscape

Study ID Alternative Stable ID Type
EGAS00000000122 Genotype/Expression

Study Description

MicroRNAs (miRNAs) are key players in cancer pathogenesis1. They display differential expression across breast cancer subtypes, and play oncogenic and tumor-suppressive roles2-6. A systematic study of the global miRNA landscape in breast cancer and the factors shaping it has not been undertaken. Here we report the results of profiling miRNA expression in 1,302 breast tumors with detailed clinical annotation and long-term follow-up, and for which matching genomic and mRNA expression data were available7. This provides a comprehensive view of the quantity, distribution and variation of the miRNA population and dissects how much genomic, transcriptional and post-transcriptional events contribute to miRNA expression architecture. The key clinical parameters and cellular pathways related to the miRNA landscape are identified, exemplified by context-dependent interaction with cell adhesion and Wnt signaling. Strikingly, in breast cancer miRNAs appear to act as modulators of mRNA-mRNA interactions rather than molecular switches. We demonstrate an important modulatory role for miRNAs in the ... (Show More)

Study Datasets 6 datasets.

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Dataset ID Description Technology Samples
Normalised mRNA expression
Illumina HT 12 1302
Illumina HT 12 IDAT files
Illumina HT 12 1302
Normalized miRNA expression data
Agilent ncRNA 60k 1480
Segmented copy number data
Affymetrix_SNP6_raw 1302
Affymetrix SNP 6.0 CEL files
Affymetrix_SNP6_raw 1302
Agilent ncRNA 60k txt files
Agilent ncRNA 60k 1480

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