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Matched_breast_cancer_fusion_gene_study

Genomic libraries (500 bps) will be generated from total genomic DNA derived from 40 breast cancer samples and subjected to total of eight lanes of 37 bp, paired end sequencing on the llumina GA. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000097 Illumina Genome Analyzer II Illumina HiSeq 2000 46
EGAD00001000138 Illumina Genome Analyzer II Illumina HiSeq 2000 58
EGAD00001001335 Illumina Genome Analyzer II Illumina HiSeq 2000 28
EGAD00001001338 Illumina Genome Analyzer II Illumina HiSeq 2000 49
EGAD00001002237 Illumina Genome Analyzer II Illumina HiSeq 2000 59
Publications Citations
The life history of 21 breast cancers.
Cell 149: 2012 994-1007
854
Mutational processes molding the genomes of 21 breast cancers.
Cell 149: 2012 979-993
1202
THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data.
Genome Biol 14: 2013 R80
123
Towards accurate characterization of clonal heterogeneity based on structural variation.
BMC Bioinformatics 15: 2014 299
7
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.
Cell Rep 16: 2016 2032-2046
28
Accurate Identification of Subclones in Tumor Genomes.
Mol Biol Evol 39: 2022 msac136
6
ERα-associated translocations underlie oncogene amplifications in breast cancer.
Nature 618: 2023 1024-1032
15