Whole_genome_sequencing_of_Crohn_s_disease_patients - EGA European Genome-Phenome Archive

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001000117	Myelodysplastic Syndrome Exome Sequencing	Illumina Genome Analyzer II Illumina HiSeq 2000	152
EGAD00001000401	Population based sequencing of whole genomes of Crohn's disease patients.	Illumina HiSeq 2000	2926

Publications	Citations
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J, Kennedy NA, Lamb CA, McCarthy S, Ahmad T, Edwards C, Serra EG, Hart A, Hawkey C, Mansfield JC, Mowat C, Newman WG, Nichols S, Pollard M, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson DC, Lee JC, Prescott NJ, Lees CW, Mathew CG, Parkes M, Barrett JC, Anderson CA. Nat Genet 49: 2017 186-192	91
Leveraging functional annotations in genetic risk prediction for human complex diseases. Hu Y, Lu Q, Powles R, Yao X, Yang C, Fang F, Xu X, Zhao H. PLoS Comput Biol 13: 2017 e1005589	98
Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction. Hu Y, Lu Q, Liu W, Zhang Y, Li M, Zhao H. PLoS Genet 13: 2017 e1006836	41
Identifying Crohn's disease signal from variome analysis. Wang Y, Miller M, Astrakhan Y, Petersen BS, Schreiber S, Franke A, Bromberg Y. Genome Med 11: 2019 59	16
Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies. Song S, Jiang W, Hou L, Zhao H. PLoS Comput Biol 16: 2020 e1007565	24