Samples from the Greek island of Crete, MANOLIS cohort

Study ID Alternative Stable ID Type
EGAS00001000067 Whole Genome Sequencing

Study Description

Genome-wide association studies of complex traits have been successful in identifying common variant associations, but a substantial heritability gap remains. The field of complex trait genetics is shifting towards the study of low frequency and rare variants, which are hypothesised to have larger effects. The study of these variants can be empowered by focusing on isolated populations, in which rare variants may have increased in frequency and linkage disequilibrium tends to be extended. This work focuses on isolated populations from Greece. Sequencing is very efficient in isolated populations, because variants found in a few samples will be shared by others in extended haplotype contexts, supporting accurate imputation.

Study Datasets 1 dataset.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
Whole-genome sequencing at 4x of 250 samples from the Greek isolatecollection HELIC
Illumina HiSeq 2000 250

Who archives the data?

There are no publications available