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I hope to gain insight into novel genetic aberrations present in these patients that will highlightimportant pathways that are involved in this subtype of leukaemia. It would be interesting to see ifthe mutations and pathways that are activated are consistent between the patients, or differencesare observed dependent upon whether the patient has the translocation or the PAR1 deletion. Ofnote is the high association with either numerical gains of chromosome X or numerical/structuralabnormalities of chromosome 21 (Down syndrome, iAMP21) in patients with CRLF2 deregulation. Ihope to find abnormalities linking chromosomes X and 21 to CRLF2 deregulation in BCP‐ALL. Byincluding the three patients that are normal for CRLF2, but have consistent genetic abnormalitiesfound in the experimental cohort, I expect to find genetic differences between these two groupsthat will help us to identify novel molecular targets specific to CRLF2 deregulation.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000076 Illumina HiSeq 2000 13
EGAD00001002007 Illumina HiSeq 2000 11
Publications Citations
Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.
Genes Chromosomes Cancer 56: 2017 363-372
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia.
Nat Cancer 2: 2021 835-852