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Linking genes, genomic instability and molecular subgroups in medulloblastoma

Brain tumors are the second most common pediatric cancer and carry the highest mortality rates in this age group. Medulloblastoma is the most frequent malignant brain tumor of childhood. Recent studies indicate that medulloblastoma comprises at least four sub-entities (SHH-signaling, WNT-signaling, Group-C, Group-D) that differ in molecular alterations, cell of origin, clinicopathological features and outcome. Further characterization of the entire spectrum of genomic alterations underlying the formation of these distinct groups is urgently needed to identify diagnostic and prognostic biomarkers for clinical management and uncover novel therapeutic targets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000027 Illumina Genome Analyzer IIx Illumina HiSeq 2000 8
EGAD00001000697 Illumina Genome Analyzer IIx Illumina HiSeq 2000 90
EGAD00001001624 Illumina HiSeq 2000 188
EGAD00001001625 Illumina Genome Analyzer IIx Illumina HiSeq 2000 209
Publications Citations
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.
Cell 148: 2012 59-71