Linking genes, genomic instability and molecular subgroups in medulloblastoma
Brain tumors are the second most common pediatric cancer and carry the highest mortality rates in this age group. Medulloblastoma is the most frequent malignant brain tumor of childhood. Recent studies indicate that medulloblastoma comprises at least four sub-entities (SHH-signaling, WNT-signaling, Group-C, Group-D) that differ in molecular alterations, cell of origin, clinicopathological features and outcome. Further characterization of the entire spectrum of genomic alterations underlying the formation of these distinct groups is urgently needed to identify diagnostic and prognostic biomarkers for clinical management and uncover novel therapeutic targets.
- Type: Whole Genome Sequencing
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001000027||Illumina Genome Analyzer IIx Illumina HiSeq 2000||8|
|EGAD00001000697||Illumina Genome Analyzer IIx Illumina HiSeq 2000||90|
|EGAD00001001624||Illumina HiSeq 2000||188|
|EGAD00001001625||Illumina Genome Analyzer IIx Illumina HiSeq 2000||209|
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.
Cell 148: 2012 59-71