Study

Linking genes, genomic instability and molecular subgroups in medulloblastoma

Study ID Alternative Stable ID Type
EGAS00001000085 Whole Genome Sequencing

Study Description

Brain tumors are the second most common pediatric cancer and carry the highest mortality rates in this age group. Medulloblastoma is the most frequent malignant brain tumor of childhood. Recent studies indicate that medulloblastoma comprises at least four sub-entities (SHH-signaling, WNT-signaling, Group-C, Group-D) that differ in molecular alterations, cell of origin, clinicopathological features and outcome. Further characterization of the entire spectrum of genomic alterations underlying the formation of these distinct groups is urgently needed to identify diagnostic and prognostic biomarkers for clinical management and uncover novel therapeutic targets.

Study Datasets 4 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000027
ICGC Germany PedBrain Medulloblastoma Pilot_2_LM
Illumina HiSeq 2000,Illumina Genome Analyzer IIx 8
EGAD00001000697
Illumina HiSeq sequence data (with >30x coverage) were aligned to the hg19 human reference genome assembly using BWA (Li and Durbin, 2009); duplicate reads were removed from the final BAM file. No realignment or recalibration was performed.
Illumina HiSeq 2000,Illumina Genome Analyzer IIx 90
EGAD00001001624
release_2: ICGC PedBrain: whole exome sequencing and Target-Seq
Illumina HiSeq 2000 188
EGAD00001001625
release_2: ICGC PedBrain: whole genome sequencing
Illumina Genome Analyzer IIx,Illumina HiSeq 2000 209

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