Study
Linking genes, genomic instability and molecular subgroups in medulloblastoma
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001000085 | Whole Genome Sequencing |
Study Description
Brain tumors are the second most common pediatric cancer and carry the highest mortality rates in this age group. Medulloblastoma is the most frequent malignant brain tumor of childhood. Recent studies indicate that medulloblastoma comprises at least four sub-entities (SHH-signaling, WNT-signaling, Group-C, Group-D) that differ in molecular alterations, cell of origin, clinicopathological features and outcome. Further characterization of the entire spectrum of genomic alterations underlying the formation of these distinct groups is urgently needed to identify diagnostic and prognostic biomarkers for clinical management and uncover novel therapeutic targets.
Study Datasets 4 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001000027 |
ICGC Germany PedBrain Medulloblastoma Pilot_2_LM
|
Illumina Genome Analyzer IIx,Illumina HiSeq 2000 | 8 |
| EGAD00001000697 |
Illumina HiSeq sequence data (with >30x coverage) were aligned to the hg19 human reference genome assembly using BWA (Li and Durbin, 2009); duplicate reads were removed from the final BAM file. No realignment or recalibration was performed.
|
Illumina Genome Analyzer IIx,Illumina HiSeq 2000 | 90 |
| EGAD00001001624 |
release_2: ICGC PedBrain: whole exome sequencing and Target-Seq
|
Illumina HiSeq 2000 | 188 |
| EGAD00001001625 |
release_2: ICGC PedBrain: whole genome sequencing
|
Illumina Genome Analyzer IIx,Illumina HiSeq 2000 | 209 |
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