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UK10K COHORT TWINSUK

The UK10K project proposes a series of complementary genetic approaches to find new low-frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome-wide sequence of 4000 samples from the TwinsUK and ALSPAC cohorts (at 6x sequence coverage), and the exome sequence (protein-coding regions and related conserved sequence) of 6000 samples selected for extreme phenotypes. Our studies will focus primarily on cardiovascular-related quantitative traits, obesity and related metabolic traits, neurodevelopmental disorders and a limited number of extreme clinical phenotypes that will provide proof-of-concept for future familial trait sequencing. We will directly analyse quantitative traits in the cohorts and the selected traits in the extreme samples, and also use imputation down to 0.1% allele frequency to extend the analyses to further sample sets with genome wide genotype data. In each case we will investigate indels and larger structural variants as well as SNPs, and use statistical methods that combine rare variants in a locus or pathway as well as single-variant approaches. The TwinsUK samples will be part of the cohort study and will undergo whole genome sequencing. For further information with regard to this cohort please contact Brent Richards (brent.richards@kcl.ac.uk) or Nicole Soranzo (ns6@sanger.ac.uk).

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000194 Illumina Genome Analyzer II Illumina HiSeq 2000 1713
EGAD00001000741 Illumina Genome Analyzer II Illumina HiSeq 2000 1854
EGAD00001000776 Illumina Genome Analyzer II Illumina HiSeq 2000 3781
EGAD00001000790 1854
Publications Citations
Detecting identity by descent and estimating genotype error rates in sequence data.
Am J Hum Genet 93: 2013 840-851
98
A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.
Nat Commun 4: 2013 2872
63
Whole-genome sequence-based analysis of thyroid function.
Nat Commun 6: 2015 5681
58
Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer.
PLoS One 10: 2015 e0122589
16
An interactive genome browser of association results from the UK10K cohorts project.
Bioinformatics 31: 2015 4029-4031
8
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Nature 526: 2015 112-117
315
The UK10K project identifies rare variants in health and disease.
Nature 526: 2015 82-90
601
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel.
Nat Commun 6: 2015 8111
190
Genome-wide association study identifies multiple susceptibility loci for glioma.
Nat Commun 6: 2015 8559
74
The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A.
Sci Rep 5: 2015 15065
24
Timing, rates and spectra of human germline mutation.
Nat Genet 48: 2016 126-133
303
A Protein Domain and Family Based Approach to Rare Variant Association Analysis.
PLoS One 11: 2016 e0153803
2
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.
Nat Commun 7: 2016 12050
97
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.
Nat Genet 48: 2016 1303-1312
50
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.
Leukemia 31: 2017 573-579
53
Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy.
Neurology 87: 2016 1975-1984
35
Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource.
Nucleic Acids Res 44: 2016 9611-9623
14
A combined reference panel from the 1000 Genomes and UK10K projects improved rare variant imputation in European and Chinese samples.
Sci Rep 6: 2016 39313
23
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Nat Commun 8: 2017 14175
49
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
Nat Genet 49: 2017 789-794
178
GeneImp: Fast Imputation to Large Reference Panels Using Genotype Likelihoods from Ultralow Coverage Sequencing.
Genetics 206: 2017 91-104
19
Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data.
Genome Biol 18: 2017 86
54
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
Am J Hum Genet 100: 2017 865-884
89
The impact of rare variation on gene expression across tissues.
Nature 550: 2017 239-243
129
Independent impacts of aging on mitochondrial DNA quantity and quality in humans.
BMC Genomics 18: 2017 890
78
De novo mutations implicate novel genes in systemic lupus erythematosus.
Hum Mol Genet 27: 2018 421-429
24
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
Nat Commun 8: 2017 1892
28
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.
Sci Rep 8: 2018 1300
36
Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.
Cell 173: 2018 53-61.e9
136
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nat Commun 9: 2018 1340
45
Combined linkage and association analysis of classical Hodgkin lymphoma.
Oncotarget 9: 2018 20377-20385
7
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.
Neuro Oncol 20: 2018 1485-1493
15
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Blood 132: 2018 2040-2052
15
ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.
PLoS Genet 14: 2018 e1007591
21
Detecting the dominance component of heritability in isolated and outbred human populations.
Sci Rep 8: 2018 18048
3
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume.
Nat Commun 10: 2019 357
14
Mendelian randomization provides support for obesity as a risk factor for meningioma.
Sci Rep 9: 2019 309
14
Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait.
Genetics 212: 2019 577-586
1
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.
Nat Commun 10: 2019 2164
51
An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations.
PLoS Genet 15: 2019 e1008340
12
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.
Nat Commun 10: 2019 5348
44
Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data.
Nat Commun 11: 2020 2061
6
Extension of SKAT to multi-category phenotypes through a geometrical interpretation.
Eur J Hum Genet 29: 2021 736-744
1
An Evaluation of the Diagnostic Accuracy of a Panel of Variants in DPYD and a Single Variant in ENOSF1 for Predicting Common Capecitabine Related Toxicities.
Cancers (Basel) 13: 2021 1497
7
Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape.
Commun Biol 4: 2021 1064
13
Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors.
Nat Commun 12: 2021 7117
25
Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics.
Nat Commun 12: 2021 7274
31
Whole-genome risk prediction of common diseases in human preimplantation embryos.
Nat Med 28: 2022 513-516
18
Genetic and phenotypic links between obesity and extracellular vesicles.
Hum Mol Genet 31: 2022 3643-3651
1
Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology.
Nat Commun 13: 2022 6490
9
Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases.
Nat Commun 13: 2022 7559
13
Multi-layered genetic approaches to identify approved drug targets.
Cell Genom 3: 2023 100341
5
Dual-systems models of the genetic architecture of impulsive personality traits: neurogenetic evidence of distinct but related factors.
Psychol Med 54: 2024 1533-1543
1
Exploring quantitative traits-associated copy number deletions through reanalysis of UK10K consortium whole genome sequencing cohorts.
BMC Genomics 24: 2023 787
0
Genetic determinants of IgG antibody response to COVID-19 vaccination.
Am J Hum Genet 111: 2024 181-199
0