Study

UK10K_OBESITY_SCOOP

Study ID Alternative Stable ID Type
EGAS00001000124 Exome Sequencing

Study Description

In the UK10K project we propose a series of complementary genetic approaches to find new low frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome wide sequence of 4000 samples from the TwinsUK and ALSPAC cohorts (at 6x sequence coverage), and the exome sequence (protein coding regions and related conserved sequence) of 6000 samples selected for extreme phenotypes. Our studies will focus primarily on cardiovascular-related quantitative traits, obesity and related metabolic traits, neurodevelopmental disorders and a limited number of extreme clinical phenotypes that will provide proof-of-concept for future familial trait sequencing. We will analyse directly quantitative traits in the cohorts and the selected traits in the extreme samples, and also use imputation down to 0.1% allele frequency to extend the analyses to further sample sets with genome wide genotype data. In each case we will investigate indels and larger structural variants as well as SNPs, and use statistical methods that combine rare variants in a locus or pathway as ... (Show More)

Study Datasets 8 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000151
UK10K OBESITY REL-2011-07-14
Illumina HiSeq 2000 88
EGAD00001000181
UK10K_OBESITY_SCOOP REL-2012-01-13
Illumina HiSeq 2000 212
EGAD00001000193
UK10K_OBESITY_SCOOP REL-2012-02-22
Illumina HiSeq 2000 573
EGAD00001000241
EGAD00001000241_UK10K_OBESITY_SCOOP_REL_2012_07_05
Illumina HiSeq 2000 674
EGAD00001000336
UK10K_OBESITY_SCOOP REL-2012-11-27
Illumina HiSeq 2000 784
EGAD00001000432
UK10K_OBESITY_SCOOP REL-2013-04-20
Illumina HiSeq 2000 985
EGAD00001000756
UK10K_OBESITY_SCOOP UK10K_EXOME_EXTRAS
Illumina HiSeq 2000 1
EGAD00001001456
1000Genomes imputed data set of 581 cases and 417 controls for male-pattern baldness
1

Who archives the data?

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