Study

UK10K_RARE_THYROID

Study ID Alternative Stable ID Type
EGAS00001000131 Exome Sequencing

Study Description

In the UK10K project we propose a series of complementary genetic approaches to find new low frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome wide sequence of 4000 samples from the TwinsUK and ALSPAC cohorts (at 6x sequence coverage), and the exome sequence (protein coding regions and related conserved sequence) of 6000 samples selected for extreme phenotypes. Our studies will focus primarily on cardiovascular-related quantitative traits, obesity and related metabolic traits, neurodevelopmental disorders and a limited number of extreme clinical phenotypes that will provide proof-of-concept for future familial trait sequencing. We will analyse directly quantitative traits in the cohorts and the selected traits in the extreme samples, and also use imputation down to 0.1% allele frequency to extend the analyses to further sample sets with genome wide genotype data. In each case we will investigate indels and larger structural variants as well as SNPs, and use statistical methods that combine rare variants in a locus or pathway as ... (Show More)

Study Datasets 6 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000152
UK10K_RARE_THYROID REL-2012-01-13
Illumina Genome Analyzer II,Illumina HiSeq 2000 27
EGAD00001000187
UK10K_RARE_THYROID REL-2012-02-22
Illumina Genome Analyzer II,Illumina HiSeq 2000 65
EGAD00001000208
UK10K_RARE_THYROID REL-2012-07-05
Illumina Genome Analyzer II,Illumina HiSeq 2000 65
EGAD00001000329
UK10K_RARE_THYROID REL-2012-11-27
Illumina Genome Analyzer II,Illumina HiSeq 2000 113
EGAD00001000420
UK10K_RARE_THYROID REL-2013-04-20
Illumina Genome Analyzer II,Illumina HiSeq 2000 124
EGAD00001000805
UK10K_RARE_THYWG REL-2013-03-06
Illumina HiSeq 2000 2

Who archives the data?

There are no publications available