Study
The clonal and mutational evolution spectrum of primary triple negative breast cancers
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00001000132 | Exome Sequencing |
Study Description
Primary triple negative breast cancers (TNBC) represent approximately 16% of all breast cancers and are a tumour type defined by exclusion,for which comprehensive landscapes of somatic mutation have not been determined. Here we show in 104 early TNBC cases, that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some exhibiting only a handful of somatic aberrations in a few pathways, whereas others contain hundreds of somatic events and multiple pathways implicated. Integration with matched whole transcriptome sequence data revealed that only 36% of mutations are expressed. By examining single nucleotide variant (SNV) allelic abundance derived from deep re-sequencing (median > 20,000 fold) measurements in 2414 somatic mutations, we determine for the first time in an epithelial tumour, the relative abundance of clonal genotypes among cases in the population. We show that TNBC vary widely and continuously in their clonal frequencies at the time of diagnosis, with basal subtype TNBC exhibiting more variation than non-basal TNBC. ... (Show More)
Study Datasets 4 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001000113 |
Mutational landscapes of primary triple negative breast cancers - Exomes
|
Illumina Genome Analyzer IIx | 108 |
EGAD00001000115 |
Mutational landscapes of primary triple negative breast cancers - WGS
|
ABI_SOLID | 32 |
EGAD00001000132 |
Mutational landscapes of primary triple negative breast cancers - RNA seq
|
Illumina Genome Analyzer IIx | 80 |
EGAD00010000148 |
tumour samples using Affymetrix Genome-Wide SNP6.0 arrays
|
Affymetrix_GenomeWide_SNP6.34 | 104 |
Who archives the data?

Publications
Citations
Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...

Retrieving...
