BRAF and MEK resistant cell line clones

Study ID Alternative Stable ID Type
EGAS00001000172 Cancer Genomics

Study Description

The Sanger Institute has the largest collection of genetically-characterised cancer cell lines world-wide (we have collected >1000 human cancer cell lines which are being screened against >400 cancer therapeutics ( These lines have been characterized to the level of gene copy number, gene expression and cancer gene mutation sequence data. This has enabled us to select melanoma lines with varying BRAF mutational status and that show sensitivity to a range of BRAF inhibitors. Sensitive lines are being used to generate resistant clones by serial exposure to increasing concentrations of BRAF and MEK inhibitors and these are being characterised by genome-wide copy number analysis as well as by whole exome sequencing.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
BRAF and MEK resistant cell line clones
Illumina HiSeq 2000 3

Who archives the data?

There are no publications available