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Somatic Histone H3 Mutations in Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Paediatric Glioblastomas

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000085 Illumina HiSeq 2000 14
EGAD00001000806 Illumina HiSeq 2000 63
EGAD00001000807 Illumina HiSeq 2000 148
EGAD00001001432 Illumina HiSeq 2000 1337
EGAD00001001433 Illumina HiSeq 2000 906
EGAD00001003905 Illumina HiSeq 2000 66
Publications Citations
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data.
Genome Biol 13: 2012 R113
Genomic landscape of paediatric adrenocortical tumours.
Nat Commun 6: 2015 6302
ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability.
Mol Cell Oncol 3: 2016 e1167158
Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma.
Oncotarget 7: 2016 65696-65706
Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas.
NPJ Genom Med 2: 2017 29
H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.
Elife 7: 2018 e36696
Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.
Nat Med 24: 2018 1204-1215
Structure and evolution of double minutes in diagnosis and relapse brain tumors.
Acta Neuropathol 137: 2019 123-137
Landscape of Germline and Somatic Mitochondrial DNA Mutations in Pediatric Malignancies.
Cancer Res 79: 2019 1318-1330
Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors.
Cancers (Basel) 12: 2020 E506
CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data.
Genome Biol 21: 2020 126
The evolution of relapse of adult T cell acute lymphoblastic leukemia.
Genome Biol 21: 2020 284
The landscape of coding RNA editing events in pediatric cancer.
BMC Cancer 21: 2021 1233
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.
Nat Cancer 3: 2022 994-1011
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Nat Cancer 4: 2023 276-289
Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.
Nucleic Acids Res 52: 2024 2372-2388