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Acute_Lymphoblastic_Leukemia_Exome_sequencing_2_

Agilent whole exome hybridisation capture will be performed on genomic DNA derived from 50 Acute Lymphoblastic Leukemia samples and matched normal DNA from the same patients. Three lanes of Illumina GA sequencing will be performed on the resulting 100 exome libraries and mapped build 37 of the human reference genome to facilitate the identification of novel cancer genes. In addition, 500bp, NO_PCR total genomic libraries will be prepared from the same samples and five lanes of Illumina GA sequencing will be analysed to characterise genome wide, somatically acquired structural variation.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000104 Illumina Genome Analyzer II 97
EGAD00001000636 Illumina Genome Analyzer II 117
Publications Citations
Single-cell mutational profiling and clonal phylogeny in cancer.
Genome Res 23: 2013 2115-2125
80
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.
Nat Genet 46: 2014 116-125
222
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia.
Nat Cancer 2: 2021 835-852
15