Acute Myeloid Leukemia Sequencing

Study ID Alternative Stable ID Type
EGAS00001000209 Cancer Genomics

Study Description

Genomic libraries (500 bps) will be generated from total genomic DNA derived from 25 acute myeloid leukemia samples and subjected to total of eight lanes of 37 bp, paired end sequencing on the llumina GA. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
Acute Myeloid Leukemia Sequencing
Illumina Genome Analyzer II,Illumina HiSeq 2000 9
Changes in gene dosage are a major driver of cancer1, engineered from a finite, but increasingly well annotated, repertoire of mutational mechanisms2-6. These processes operate over levels ranging from individual exons to whole chromosomes, often generating correlated copy number alterations across hundreds of linked genes. An example of the latter is the 2% of childhood acute lymphoblastic leukemia (ALL) characterized by recurrent intrachromosomal amplification of megabase regions of ... (Show More)
Illumina Genome Analyzer II,Illumina HiSeq 2000 9

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