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Assessment_of_genetic_and_epigenetic_variation_in_human_IPS_cells

In order to progress human induced pluripotent stem cells (hiPSCs) towards the clinic, several outstanding questions must be addressed. It is possible to reprogram different somatic cell types into hiPSCs but it is unclear whether some cell types carry through fewer mutations through reprogramming (either due to mutations present in the primary cells, or mutations accumulated during reprogramming). Through in depth analysis of hiPSCs generated from different somatic cells, it will be possible to assess the variation in genetic stability of different cell types.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000798 Illumina HiSeq 2000 Illumina HiSeq 2500 Illumina MiSeq 28
Publications Citations
Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.
PLoS Genet 12: 2016 e1005932
56