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Genetic landscape of pediatric Rhabdomyosarcoma

We performed whole-genome sequencing of 13 paired tumor/normal Rhabdomyosarcoma genomes and analyzed somatically acquired single nucleotide variations SNVs, insertion/deletions, structural variations and copy number variations in the cancer genomes

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000164 Illumina HiSeq 2000 29
EGAD00001000878 Illumina HiSeq 2000 42
EGAD00001001059 Illumina HiSeq 2000 56
EGAD00001001432 Illumina HiSeq 2000 1337
EGAD00001001433 Illumina HiSeq 2000 906
EGAD00010001596 Illlimuna EPIC 450 K 32
Publications Citations
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data.
Genome Biol 13: 2012 R113
Targeting oxidative stress in embryonal rhabdomyosarcoma.
Cancer Cell 24: 2013 710-724
Development and characterization of a human orthotopic neuroblastoma xenograft.
Dev Biol 407: 2015 344-355
The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities.
Dev Biol 411: 2016 287-293
PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.
Elife 7: 2018 e33800
Barriers to accessing public cancer genomic data.
Sci Data 6: 2019 98
Bayesian Modeling Identifies PLAG1 as a Key Regulator of Proliferation and Survival in Rhabdomyosarcoma Cells.
Mol Cancer Res 18: 2020 364-374
CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data.
Genome Biol 21: 2020 126
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
Cell Rep 33: 2020 108493
The landscape of coding RNA editing events in pediatric cancer.
BMC Cancer 21: 2021 1233
Exon skipping in genes encoding lineage-defining myogenic transcription factors in rhabdomyosarcoma.
Cold Spring Harb Mol Case Stud None: 2022 mcs.a006190
Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice.
Commun Biol 5: 2022 992
VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis.
Cell Rep 42: 2023 112013
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Nat Cancer 4: 2023 276-289
Methyltransferase Inhibition Enables Tgf<b>β</b> Driven Induction of <i>CDKN2A</i> and <i>B</i> in Cancer Cells.
Mol Cell Biol 43: 2023 115-129