Study

AML targeted resequencing study

Study ID Alternative Stable ID Type
EGAS00001000275 Cancer Genomics

Study Description

Genomic libraries will be generated from whole genome amplified genomic DNA derived from 3,000 myeloid neoplasms. Targeted capture will be performed by multiplexing 16 barcoded samples in each library. Pools of 96 DNA samples will be subjected to 1-2 lanes of HiSeq 75bp sequencing. Reads will be mapped to the current build of the human reference genome to facilitate the generation of a comprehensive catalog of somatic mutations associated with 116 known myeloid and cancer driver genes.

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
EGAD00001000253
AML targeted resequencing study
Illumina HiSeq 2000 N/A
EGAD00001000283
Agilent whole exome hybridisation capture was performed on genomic DNA derived from MDS and matched normal DNA from the same patients. Next Generation sequencing performed on the resulting exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes. Now we aim to discover the prevalence of our findings using bespoke pulldown methods and sequencing the products from a larger set of patient DNA.
Illumina HiSeq 2000 764

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