AML_targeted_resequencing_study - EGA European Genome-Phenome Archive

Study ID	Alternative Stable ID	Type
EGAS00001000275		Cancer Genomics

Study ID

Alternative Stable ID

Type

EGAS00001000275

Cancer Genomics

Study Description

Genomic libraries will be generated from whole genome amplified genomic DNA derived from 3,000 myeloid neoplasms. Targeted capture will be performed by multiplexing 16 barcoded samples in each library. Pools of 96 DNA samples will be subjected to 1-2 lanes of HiSeq 75bp sequencing. Reads will be mapped to the current build of the human reference genome to facilitate the generation of a comprehensive catalog of somatic mutations associated with 116 known myeloid and cancer driver genes.

Dataset ID	Description	Technology	Samples
EGAD00001000253	AML targeted resequencing study AML targeted resequencing study	Illumina HiSeq 2000	N/A
EGAD00001000283	Agilent whole exome hybridisation capture was performed on genomic DNA derived from MDS and matched normal DNA from the same patients. Next Generation sequencing performed on the resulting exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes. Now we aim to discover the prevalence of our findings using bespoke pulldown methods and sequencing the products from a larger set of patient DNA. Agilent whole exome hybridisation capture was performed on genomic DNA derived from MDS and matched normal DNA from the same patients. Next Generation sequencing performed on the resulting exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes. Now we aim to discover the prevalence of our findings using bespoke pulldown methods and sequencing the products from a larger set of patient DNA.	Illumina HiSeq 2000	764

Dataset ID

Description

Technology

Samples

EGAD00001000253

AML targeted resequencing study

Illumina HiSeq 2000

N/A

EGAD00001000283

Agilent whole exome hybridisation capture was performed on genomic DNA derived from MDS and matched normal DNA from the same patients. Next Generation sequencing performed on the resulting exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes. Now we aim to discover the prevalence of our findings using bespoke pulldown methods and sequencing the products from a larger set of patient DNA.

Illumina HiSeq 2000

764

Study

Study Description

Study Datasets 2 datasets.

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Publications

Citations

The European Genome-phenome Archive (EGA) is part of the ELIXIR infrastructure.