Genetic landscape of pediatric Medulloblastoma
|Study ID||Alternative Stable ID||Type|
|EGAS00001000347||Whole Genome Sequencing|
Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whole genome sequencing of 37 medulloblastomas and the corresponding normal DNA of the 37 affected children treated at St. Jude Children's Research Hospital. We have found several novel mutations which appear subtype specific. These mutations were checked for frequency in a separate tumor cohort of 56 children with medulloblastoma, also treated on the St. Jude Medulloblastoma 2003 trial, and were tested in several animal models of medulloblastoma for proof of oncogenic potential.
Study Datasets 3 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
OLD DATA FILES FOR SJMB - Superseded by EGAD00001001864
|Illumina HiSeq 2000||68|
PCGP Germline Study Whole Genome Sequencing
|Illumina HiSeq 2000||1337|
DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)
|Illumina HiSeq 2000||76|
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