Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
|Study ID||Alternative Stable ID||Type|
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Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. To determine the genetic basis for neuroblastoma we performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases), and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing. On average each tumor had 19 somatic alterations in coding genes (range, 3-70). Among genes not previously known to ... (Show More)
|Illumina Genome Analyzer IIx,Illumina HiSeq 2000||114|