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Deep RNA sequencing in CLL

Chronic lymphocytic leukemia (CLL) is a B-cell neoplasm with a heterogeneous clinical and biological behavior. We have performed deep RNA sequencing in different subpopulations of B-lymphocytes from healthy individuals and CLL cells from a cohort of 98 patients, and characterized the CLL transcriptional landscape with unprecedented resolution. The transcriptomic architecture of CLL uncovered here refines the biological characterization of the disease and opens new perspectives for the clinical management of patients.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000083 Illumina Genome Analyzer II Illumina Genome Analyzer IIx 61
EGAD00001000258 Illumina Genome Analyzer II 107
EGAD00010000472 Affymetrix U219 219
Publications Citations
Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia.
Genome Res 24: 2014 212-226
Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLL.
Clin Epigenetics 8: 2016 106
Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia.
J Cell Mol Med 22: 2018 2846-2855
Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia.
Biol Sex Differ 10: 2019 2
Time to Treatment Prediction in Chronic Lymphocytic Leukemia Based on New Transcriptional Patterns.
Front Oncol 9: 2019 79
New Recurrent Structural Aberrations in the Genome of Chronic Lymphocytic Leukemia Based on Exome-Sequencing Data.
Front Genet 10: 2019 854
RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia.
Leukemia 35: 2021 1053-1063
SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2.
Leukemia 35: 2021 1073-1086
Detecting Bacterial-Human Lateral Gene Transfer in Chronic Lymphocytic Leukemia.
Int J Mol Sci 23: 2022 1094
Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells.
Front Immunol 13: 2022 840388
Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling.
PLoS Comput Biol 18: 2022 e1010438
Genome-wide DNA methylation profiling in chronic lymphocytic leukaemia.
Front Genet 13: 2022 1056043
StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling.
PLoS Comput Biol 20: 2024 e1012022