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Whole-genome sequencing analysis of low-grade astrocytomas within the ICGC PedBrain Tumor Project

In order to investigate the full range of genetic alterations contributing to the tumourigenesis of low-grade astrocytoma, we have conducted a next-generation sequencing-based analysis on a large series of matched tumor-normal pairs. This study, conducted by the International Cancer Genome Consortium PedBrain Tumor Project (ICGC PedBrain,, has revealed multiple new insights into the biological basis of this tumor entity.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000271 Illumina HiSeq 2000 10
EGAD00001000616 Illumina HiSeq 2000 192
EGAD00001000617 Illumina HiSeq 2000 73
Publications Citations
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Nat Genet 45: 2013 927-932
confFuse: High-Confidence Fusion Gene Detection across Tumor Entities.
Front Genet 8: 2017 137
Pilocytic astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response.
Neuro Oncol 22: 2020 1327-1338
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.
Acta Neuropathol 146: 2023 551-564