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Integrative genomic analyses reveal androgen-driven somatic alteration landscape in early-onset prostate cancer

Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in eleven tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of >10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000303 Illumina Genome Analyzer IIx 22
EGAD00001000304 Illumina HiSeq 2000 8
EGAD00001000305 Illumina HiSeq 2000 12
EGAD00001000306 Illumina HiSeq 2000 22
EGAD00001000632 AB SOLiD 4 System 12
EGAD00001007861 Illumina HiSeq 2000 320
Publications Citations
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.
Cancer Cell 23: 2013 159-170
Transcription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis?
OMICS 18: 2014 615-624
Quantifying the influence of mutation detection on tumour subclonal reconstruction.
Nat Commun 11: 2020 6247
The telomere length landscape of prostate cancer.
Nat Commun 12: 2021 6893