Integrative genomic analyses reveal androgen-driven somatic alteration landscape in early-onset prostate cancer
Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in eleven tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of >10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001000303||Illumina Genome Analyzer IIx||22|
|EGAD00001000304||Illumina HiSeq 2000||8|
|EGAD00001000305||Illumina HiSeq 2000||12|
|EGAD00001000306||Illumina HiSeq 2000||22|
|EGAD00001000632||AB SOLiD 4 System||12|
|EGAD00001007861||Illumina HiSeq 2000||320|
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