Study

Integrative genomic analyses reveal androgen-driven somatic alteration landscape in early-onset prostate cancer

Study ID Alternative Stable ID Type
EGAS00001000400 Other

Study Description

Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in eleven tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of >10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.

Study Datasets 5 datasets.

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Dataset ID Description Technology Samples
EGAD00001000303
ICGC prostate cancer whole genome mate-pair sequencing
Illumina Genome Analyzer IIx 22
EGAD00001000304
ICGC prostate cancer miRNA sequencing
Illumina HiSeq 2000 8
EGAD00001000305
ICGC prostate cancer RNA sequencing
Illumina HiSeq 2000 12
EGAD00001000306
ICGC prostate cancer whole genome sequencing
Illumina HiSeq 2000 22
EGAD00001000632
NA
AB SOLiD 4 System 12

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